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Motor-neuron-disease-like phenotype associated with IgLON5 disease.
Sista, Sri Raghav; Crum, Brian; Aboseif, Albert; Devine, Michelle F; Zekeridou, Anastasia; Hammami, M Bakri; Rezk, Mohammed M; Truffert, André; Lalive, Patrice H; Kunchok, Amy; McKeon, Andrew; Dubey, Divyanshu.
Afiliação
  • Sista SR; Laboratory Medicine and Pathology, Department of Neurology, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA.
  • Crum B; Laboratory Medicine and Pathology, Department of Neurology, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA.
  • Aboseif A; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Devine MF; Laboratory Medicine and Pathology, Department of Neurology, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA.
  • Zekeridou A; Laboratory Medicine and Pathology, Department of Neurology, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA.
  • Hammami MB; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Rezk MM; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.
  • Truffert A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Lalive PH; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Kunchok A; Division of Neurology, Department of Neurosciences, Faculty of Medicine, University Hospital of Geneva, Geneva, Switzerland.
  • McKeon A; Division of Neurology, Department of Neurosciences, Faculty of Medicine, University Hospital of Geneva, Geneva, Switzerland.
  • Dubey D; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
J Neurol ; 269(11): 6139-6144, 2022 Nov.
Article em En | MEDLINE | ID: mdl-35857139
ABSTRACT
A growing spectrum of neurological manifestations are being recognized in association with IgLON5 autoimmunity, including recent reports of motor-neuron-disease-like phenotype. Here we describe four cases of IgLON5 autoimmunity with motor neuron involvement and evaluate an additional 109 probable or definite amyotrophic lateral sclerosis cases seen in our neuromuscular clinic for IgLON5-IgG seropositivity. The presence of parasomnias, vocal cord dysfunction or hyperkinetic movements in a patient with motor-neuron-disease-like phenotype should prompt evaluation for IgLON5-IgG autoantibodies. Recognition and treatment of this autoimmune disease with immunosuppressive agents may bring about significant neurological improvement in a minority of cases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article