Determination of the Number of Tissue Groups of Kinetically Distinct Transit Time in Whole-Body Physiologically Based Pharmacokinetic (PBPK) Models I: Theoretical Consideration of Bottom-Up Approach of Lumping Tissues in Whole-Body PBPK.

Jeong, Yoo-Seong; Kim, Min-Soo; Chung, Suk-Jae

Jeong, Yoo-Seong; Kim, Min-Soo; Chung, Suk-Jae.

Afiliação

Jeong YS; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
Kim MS; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
Chung SJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea. sukjae@snu.ac.kr.

AAPS J ; 24(5): 90, 2022 08 24.

Article em En | MEDLINE | ID: mdl-36002760

Assuntos

Modelos Biológicos; Farmacocinética

Palavras-chave

Bottom-up approach; Minimal PBPK; Number of tissue group; Tissue lumping; Whole-body PBPK

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article