Simultaneous imaging of redox states in dystrophic neurites and microglia at Aß plaques indicate lysosome accumulation not microglia correlate with increased oxidative stress.

Wendt, Stefan; Johnson, Sora; Weilinger, Nicholas L; Groten, Christopher; Sorrentino, Stefano; Frew, Jonathan; Yang, Lucy; Choi, Hyun B; Nygaard, Haakon B; MacVicar, Brian A

Wendt, Stefan; Johnson, Sora; Weilinger, Nicholas L; Groten, Christopher; Sorrentino, Stefano; Frew, Jonathan; Yang, Lucy; Choi, Hyun B; Nygaard, Haakon B; MacVicar, Brian A.

Afiliação

Wendt S; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, V6T 1Z3, Canada. Electronic address: stefan.wendt@ubc.ca.
Johnson S; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, V6T 1Z3, Canada.
Weilinger NL; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, V6T 1Z3, Canada.
Groten C; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, V6T 1Z3, Canada.
Sorrentino S; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, V6T 1Z3, Canada.
Frew J; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, V6T 1Z3, Canada.
Yang L; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, V6T 1Z3, Canada.
Choi HB; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, V6T 1Z3, Canada.
Nygaard HB; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, V6T 1Z3, Canada.
MacVicar BA; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, V6T 1Z3, Canada. Electronic address: bmacvicar@brain.ubc.ca.

Redox Biol ; 56: 102448, 2022 10.

Article em En | MEDLINE | ID: mdl-36037587

Assuntos

Doença de Alzheimer; Placa Amiloide; Doença de Alzheimer/diagnóstico por imagem; Doença de Alzheimer/genética; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Animais; Modelos Animais de Doenças; Lisossomos/metabolismo; Camundongos; Camundongos Transgênicos; Neuritos; Oxirredução; Estresse Oxidativo; Placa Amiloide/metabolismo; Placa Amiloide/patologia; Ubiquitinas/metabolismo; Ubiquitinas/farmacologia

Palavras-chave

Alzheimer's disease; Microglia; Neurodegeneration; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article