Conserved FimH mutations in the global <i>Escherichia coli</i> ST131 multi-drug resistant lineage weaken interdomain interactions and alter adhesin function.

Qin, Jilong; Wilson, Katie A; Sarkar, Sohinee; Heras, Begoña; O'Mara, Megan L; Totsika, Makrina

Conserved FimH mutations in the global Escherichia coli ST131 multi-drug resistant lineage weaken interdomain interactions and alter adhesin function.

Qin, Jilong; Wilson, Katie A; Sarkar, Sohinee; Heras, Begoña; O'Mara, Megan L; Totsika, Makrina.

Afiliação

Qin J; Centre for Immunology and Infection Control, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD 4006, Australia.
Wilson KA; Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.
Sarkar S; Centre for Immunology and Infection Control, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD 4006, Australia.
Heras B; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
O'Mara ML; Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.
Totsika M; Centre for Immunology and Infection Control, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD 4006, Australia.

Comput Struct Biotechnol J ; 20: 4532-4541, 2022.

Article em En | MEDLINE | ID: mdl-36090810

Palavras-chave

Conformational equilibrium; FimH adhesin; Mannose; Protein allostery; ST131

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article