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Cognitive dysfunction in SLE: An understudied clinical manifestation.
Mizrachi, Mark; Anderson, Erik; Carroll, Kaitlin R; Tehrani, Nazila; Volpe, Bruce T; Diamond, Betty.
Afiliação
  • Mizrachi M; Feinstein Institutes for Medical Research, Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, 350 Community Drive, Manhasset, NY, 11030, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, USA.
  • Anderson E; Feinstein Institutes for Medical Research, Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, 350 Community Drive, Manhasset, NY, 11030, USA.
  • Carroll KR; Feinstein Institutes for Medical Research, Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, 350 Community Drive, Manhasset, NY, 11030, USA.
  • Tehrani N; Feinstein Institutes for Medical Research, Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, 350 Community Drive, Manhasset, NY, 11030, USA.
  • Volpe BT; Feinstein Institutes for Medical Research, Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, 350 Community Drive, Manhasset, NY, 11030, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, USA.
  • Diamond B; Feinstein Institutes for Medical Research, Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, 350 Community Drive, Manhasset, NY, 11030, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, USA. Electronic address: bdiamond@northwell.edu.
J Autoimmun ; 132: 102911, 2022 10.
Article em En | MEDLINE | ID: mdl-36127204
Neuropsychiatric lupus (NPSLE) is a debilitating manifestation of SLE which occurs in a majority of SLE patients and has a variety of clinical manifestations. In the central nervous system, NPSLE may result from ischemia or penetration of inflammatory mediators and neurotoxic antibodies through the blood brain barrier (BBB). Here we focus on cognitive dysfunction (CD) as an NPSLE manifestation; it is common, underdiagnosed, and without specific therapy. For a very long time, clinicians ignored cognitive dysfunction and researchers who might be interested in the question struggled to find an approach to understanding mechanisms for this manifestation. Recent years, however, propelled by a more patient-centric approach to disease, have seen remarkable progress in our understanding of CD pathogenesis. This has been enabled through the use of novel imaging modalities and numerous mouse models. Overall, these studies point to a pivotal role of an impaired BBB and microglial activation in leading to neuronal injury. These insights suggest potential therapeutic modalities and make possible clinical trials for cognitive impairment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article