Integrated TCR repertoire analysis and single-cell transcriptomic profiling of tumor-infiltrating T cells in renal cell carcinoma identifies shared and tumor-restricted expanded clones with unique phenotypes.

Xu, Yuexin; Morales, Alicia J; Towlerton, Andrea M H; Akilesh, Shreeram; Miller, Chris P; Tykodi, Scott S; Warren, Edus H

Xu, Yuexin; Morales, Alicia J; Towlerton, Andrea M H; Akilesh, Shreeram; Miller, Chris P; Tykodi, Scott S; Warren, Edus H.

Afiliação

Xu Y; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Morales AJ; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Towlerton AMH; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Akilesh S; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Miller CP; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Tykodi SS; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Warren EH; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.

Front Oncol ; 12: 952252, 2022.

Article em En | MEDLINE | ID: mdl-36185254

Palavras-chave

T-cell receptor repertoire; renal cell carcinoma; single-cell RNA sequencing; tumor microenvironment (TEM); tumor-infiltrating T-cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article