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A two-residue nascent-strand steric gate controls synthesis of 2'-O-methyl- and 2'-O-(2-methoxyethyl)-RNA.
Freund, Niklas; Taylor, Alexander I; Arangundy-Franklin, Sebastian; Subramanian, Nithya; Peak-Chew, Sew-Yeu; Whitaker, Amy M; Freudenthal, Bret D; Abramov, Mikhail; Herdewijn, Piet; Holliger, Philipp.
Afiliação
  • Freund N; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
  • Taylor AI; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK. ait29@cam.ac.uk.
  • Arangundy-Franklin S; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK. ait29@cam.ac.uk.
  • Subramanian N; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
  • Peak-Chew SY; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
  • Whitaker AM; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
  • Freudenthal BD; Laboratory of Genome Maintenance and Structural Biology, Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA.
  • Abramov M; Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.
  • Herdewijn P; Laboratory of Genome Maintenance and Structural Biology, Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA.
  • Holliger P; Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
Nat Chem ; 15(1): 91-100, 2023 01.
Article em En | MEDLINE | ID: mdl-36229679

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article