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Occurrence of breast-cancer-related lymphedema after reverse lymphatic mapping and selective axillary dissection versus standard surgical treatment of axilla: A two-arm randomized clinical trial.
Gennaro, Massimiliano; Maccauro, Marco; Mariani, Luigi; Listorti, Chiara; Sigari, Carmela; De Vivo, Annarita; Chisari, Marco; Maugeri, Ilaria; Lorenzoni, Alice; Aliberti, Gianluca; Scaperrotta, Gianfranco P; Caraceni, Augusto; Pruneri, Giancarlo; Folli, Secondo.
Afiliação
  • Gennaro M; Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Maccauro M; Nuclear Medicine Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Mariani L; Department of Clinical Epidemiology and Trials Organization, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Listorti C; Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Sigari C; Palliative Care, Pain Therapy and Rehabilitation Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • De Vivo A; Palliative Care, Pain Therapy and Rehabilitation Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Chisari M; Palliative Care, Pain Therapy and Rehabilitation Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Maugeri I; Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Lorenzoni A; Nuclear Medicine Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Aliberti G; Nuclear Medicine Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Scaperrotta GP; Breast Imaging Unit, Radiology Department, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Caraceni A; Palliative Care, Pain Therapy and Rehabilitation Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Pruneri G; Pathology Department, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Folli S; Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Cancer ; 128(24): 4185-4193, 2022 12 15.
Article em En | MEDLINE | ID: mdl-36259883
BACKGROUND: The need for axillary dissection (AD) is declining, but it is still essential for many patients with nodal involvement who risk developing breast-cancer-related lymphedema (BCRL) with lifelong consequences. Previous nonrandomized studies found axillary reverse mapping and selective axillary dissection (ARM-SAD) a safe and feasible way to preserve the arm's lymphatic drainage. METHODS: The present two-arm prospective randomized clinical trial was held at a single comprehensive cancer center to ascertain whether ARM-SAD can reduce the risk of BCRL, compared with standard AD, in patients with node-positive breast cancer. Whatever the type of breast surgery or adjuvant treatments planned, 130 patients with nodal involvement met our inclusion criteria: 65 were randomized for AD and 65 for ARM-SAD. Twelve months after surgery, a physiatrist assessed patients for BCRL and calculated the excess volume of the operated arm. Lymphoscintigraphy was used to assess drainage impairment. Self-reports of any impairment were also recorded. RESULTS: The difference in the incidence of BCRL between the two groups was 21% (95% CI, 3-37; p = .03). A significantly lower rate of BCRL after ARM-SAD was confirmed by a multimodal analysis that included the physiatrist's findings, excess arm volume, and lymphoscintigraphic findings, but this was not matched by a significant difference in patients' self-reports. CONCLUSIONS: Our findings encourage a change of surgical approach when AD is still warranted. ARM-SAD may be an alternative to standard AD to reduce the treatment-related morbidity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article