Iron-catalysed reductive coupling for the synthesis of polyfluorinated compounds.
Chem Commun (Camb)
; 58(100): 13915-13918, 2022 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-36445240
ABSTRACT
Herein we reported the use of Earth-abundant iron as the catalytic metal in the presence of Mn to induce difluorobromoacetates to form carbon radicals, which reacted with trifluoromethyl olefins followed by ß-F elimination to generate the corresponding gem-difluoroolefins. The cross-electrophile coupling displayed excellent functional group tolerance and broad substrate scope under mild reductive conditions, affording a large number of polyfluorinated compounds, which could be further transformed to other valuable molecules.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article