Exploring monitoring strategies for population surveillance of HPV vaccine impact using primary HPV screening.
Tumour Virus Res
; 15: 200255, 2023 06.
Article
em En
| MEDLINE
| ID: mdl-36736490
ABSTRACT
Australia's cervical screening program transitioned from cytology to HPV-testing with genotyping for HPV16/18 in Dec'2017. We investigated whether program data could be used to monitor HPV vaccination program impact (commenced in 2007) on HPV16/18 prevalence and compared estimates with pre-vaccination benchmark prevalence. Pre-vaccination samples (2005-2008) (n = 1933; WHINURS), from 25 to 64-year-old women had been previously analysed with Linear Array (LA). Post-vaccination samples (2013-2014) (n = 2989; Compass pilot), from 25 to 64-year-old women, were analysed by cobas 4800 (cobas), and by LA for historical comparability. Age standardised pre-vaccination HPV16/18 prevalence was 4.85% (95%CI3.81-5.89) by LA; post-vaccination estimates were 1.67% (95%CI1.21-2.13%) by LA, 1.49% (95%CI1.05-1.93%) by cobas, and 1.63% (95%CI1.17-2.08%) for cobas and LA testing of non-16/18 cobas positives (cobas/LA). Age-standardised pre-vaccination oncogenic HPV prevalence was 15.70% (95%CI13.79-17.60%) by LA; post-vaccination estimates were 9.06% (95%CI8.02-10.09%) by LA, 8.47% (95%CI7.47-9.47%) by cobas and cobas/LA. Standardised rate ratios between post-vs. pre-vaccination rates were significantly different for HPV16/18, non-16/18 HPV and oncogenic HPV 0.34 (95%CI0.23-0.50), 0.68 (95%CI0.55-0.84) and 0.58 (95%CI0.48-0.69), respectively. Additional strategies (LA for all cobas positives; combined cobas and LA results on all samples) had similar results. If a single method is applied consistently, it will provide important data on relative changes in HPV prevalence following vaccination.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article