Peptide-binding specificity prediction using fine-tuned protein structure prediction networks.

Motmaen, Amir; Dauparas, Justas; Baek, Minkyung; Abedi, Mohamad H; Baker, David; Bradley, Philip

Motmaen, Amir; Dauparas, Justas; Baek, Minkyung; Abedi, Mohamad H; Baker, David; Bradley, Philip.

Afiliação

Motmaen A; Department of Biochemistry, University of Washington, Seattle, WA 98195.
Dauparas J; Institute for Protein Design, University of Washington, Seattle, WA 98195.
Baek M; Bioengineering Graduate Program, University of Washington, Seattle, WA 98195.
Abedi MH; Department of Biochemistry, University of Washington, Seattle, WA 98195.
Baker D; Institute for Protein Design, University of Washington, Seattle, WA 98195.
Bradley P; Department of Biochemistry, University of Washington, Seattle, WA 98195.

Proc Natl Acad Sci U S A ; 120(9): e2216697120, 2023 02 28.

Article em En | MEDLINE | ID: mdl-36802421

Assuntos

Antígenos de Histocompatibilidade Classe II; Peptídeos; Ligação Proteica; Peptídeos/química; Antígenos de Histocompatibilidade Classe II/metabolismo; Genes MHC da Classe II; Domínios PDZ

Palavras-chave

AlphaFold; binding specificity prediction; fine-tuning; peptide-MHC interactions; structure modeling networks

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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