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New Psychoactive Substances, New Behaviours, New Drug-drug Interactions: Pharmacology of a Slam Session.
Schreck, Benoit; Istvan, Marion; Guerlais, Marylène; Laforgue, Edouard-Jules; Gérardin, Marie; Grall-Bronnec, Marie; Aquizerate, Aurélie; Victorri-Vigneau, Caroline.
Afiliação
  • Schreck B; Nantes Université, CHU Nantes, UIC Psychiatrie et Santé Mentale, F-44000 Nantes, France.
  • Istvan M; Nantes Université, Univ Tours, CHU Nantes, CHU Tours, INSERM, MethodS in Patients Centered Outcomes and Health Research, SPHERE, F-44000 Nantes, France.
  • Guerlais M; Nantes Université, Univ Tours, CHU Nantes, CHU Tours, INSERM, MethodS in Patients Centered Outcomes and Health Research, SPHERE, F-44000 Nantes, France.
  • Laforgue EJ; Nantes Université, CHU Nantes, Centre d'Evaluation et d'Information sur la Pharmacodépendance-Addictovigilance (CEIP-A), Service de Pharmacologie Clinique, F-44000 Nantes, France.
  • Gérardin M; Nantes Université, CHU Nantes, Centre d'Evaluation et d'Information sur la Pharmacodépendance-Addictovigilance (CEIP-A), Service de Pharmacologie Clinique, F-44000 Nantes, France.
  • Grall-Bronnec M; Nantes Université, Univ Tours, CHU Nantes, CHU Tours, INSERM, MethodS in Patients Centered Outcomes and Health Research, SPHERE, F-44000 Nantes, France.
  • Aquizerate A; Nantes Université, CHU Nantes, Centre d'Evaluation et d'Information sur la Pharmacodépendance-Addictovigilance (CEIP-A), Service de Pharmacologie Clinique, F-44000 Nantes, France.
  • Victorri-Vigneau C; Nantes Université, CHU Nantes, Centre d'Evaluation et d'Information sur la Pharmacodépendance-Addictovigilance (CEIP-A), Service de Pharmacologie Clinique, F-44000 Nantes, France.
Curr Drug Metab ; 24(2): 80-91, 2023.
Article em En | MEDLINE | ID: mdl-36852802
ABSTRACT

BACKGROUND:

Slamming has been increasing internationally for ten years, mostly among men who have sex with men. Slamming consists of injecting psychostimulants (including new psychoactive substances-NPS) intravenously to increase sexual performance.

OBJECTIVE:

The objective of our work was to analyse drug-drug interactions related to slamming.

METHODS:

Drawing upon a reported case of a slam session describing hour by hour the intake of substances, we performed a drug-interaction analysis using international references and a comprehensive literature review. High doses of sildenafil, GBL and 3-MMC were reported during the 40-hour session described. The specific drug-interaction research was performed using 9 references and 65 of the 209 records identified in the literature review.

RESULTS:

Pharmacological data regarding nonmedicated substances were scarce. Regarding pharmacodynamics, the risk was high at the cardiovascular level and was related to the vasodilatation effect of sildenafil and the adrenergic and serotoninergic properties of stimulants; this risk may increase with usual treatment (involving other vasodilators or central depressants). Regarding pharmacokinetics, the major interactions concerned metabolism by CYP3A4 and CYP2C9, leading to interactions, particularly with HIV medication.

CONCLUSION:

This innovative work provides pharmacological information on drugs that are commonly used in slamming, allowing the development of effective medical-management protocols and the provision of risk-reduction counselling.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Limite: Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Limite: Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article