Remote Electronic Effect of Chiral N-Heterocyclic Carbene Catalyst on an Asymmetric Benzoin Reaction.
Chemistry
; 29(38): e202300858, 2023 Jul 06.
Article
em En
| MEDLINE
| ID: mdl-37067457
ABSTRACT
A remote electronic effect of chiral aminoindanol-derived N-heterocyclic carbene catalyst on an asymmetric benzoin reaction was investigated. The catalyst bearing remote electron-withdrawing substituents increased enantioselectivity of the reaction at the cost of the reaction rate. DFT calculations rationalized the increased enantioselectivity.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2023
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Article