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A new family of luminescent iridium complexes: synthesis, optical, and cytotoxic studies.
Millán, Gonzalo; Nieddu, Mattia; López, Icíar P; Ezquerro, Cintia; Berenguer, Jesús R; Larráyoz, Ignacio M; Pichel, José G; Lalinde, Elena.
Afiliação
  • Millán G; Departamento de Química-Centro de Síntesis Química de La Rioja, (CISQ), Universidad de La Rioja, 26006, Logroño, Spain. elena.lalinde@unirioja.es.
  • Nieddu M; Departamento de Química-Centro de Síntesis Química de La Rioja, (CISQ), Universidad de La Rioja, 26006, Logroño, Spain. elena.lalinde@unirioja.es.
  • López IP; Chair of Biogenic Functional Materials, Technical University of Munich, Schulgasse, 22, Straubing 94315, Germany.
  • Ezquerro C; Lung Cancer and Respiratory Diseases Unit (CIBIR), Fundación Rioja Salud, 26006, Logroño, Spain. jgpichel@riojasalud.es.
  • Berenguer JR; Departamento de Química-Centro de Síntesis Química de La Rioja, (CISQ), Universidad de La Rioja, 26006, Logroño, Spain. elena.lalinde@unirioja.es.
  • Larráyoz IM; Departamento de Química-Centro de Síntesis Química de La Rioja, (CISQ), Universidad de La Rioja, 26006, Logroño, Spain. elena.lalinde@unirioja.es.
  • Pichel JG; Unidad Predepartamental de Enfermería, Universidad de La Rioja, Duquesa de la Victoria 88, E-26006, Logroño, Spain. ignacio.larrayoz@unirioja.es.
  • Lalinde E; Biomarkers and Molecular Signaling Unit (CIBIR), Fundación Rioja Salud, 26006, Logroño, Spain.
Dalton Trans ; 52(19): 6360-6374, 2023 May 16.
Article em En | MEDLINE | ID: mdl-37083057
By using N,N-dibutyl-2,2'-bipyridine-4,4'-dicarboxamide as a diimine (dbbpy) and distinctive cyclometalated groups, this work reports a new family of cationic phosphorescent Ir(III) cyclometalated [Ir(C^N)2(N^N)]X compounds [C^N = difluorophenylpyridine (dfppy) a, 2,6-difluoro-3-(pyridin-2-yl)benzaldehyde (CHO-dfppy) b, and 2,6-difluoro-3-pyridin-2-yl-benzoic acid (COOH-dfppy) c; X = Cl-2a,b,c-Cl; X = PF6-2b,c-PF6]. For comparative purposes, the related complex [Ir(dfppy)2(H2dcbpy)]+ (3a-PF6) incorporating 3,3'-dicarboxy-2,2'-bipyridine as an auxiliary ligand (N^N = H2dcbpy) is also presented. All complexes have been fully characterized and their photophysical properties were investigated in detail. The theoretically calculated results obtained by density functional theory (DFT) and time-dependent density functional theory (TD-DFT) studies indicate that luminescence is derived from mixed 3ML'CT (Ir → N^N)/3LL'CT (C^N → N^N) excited states with the predominant metal-to-diimine charge transfer character. Their antineoplastic activity against tumour cell lines A549 (lung carcinoma) and HeLa (cervix carcinoma), as well as the nontumor BEAS-2B (bronchial epithelium) cell line was assessed and fluorescence microscopy studies were performed for their cellular localization. Among them, 2a-Cl exhibited the most potent anticancer activity, being higher than cisplatin. However, 2b-Cl and 2c-Cl,-PF6 were the least toxic, while 2b-PF6 and 3a-PF6 exhibited only moderate activity. Confocal microscopy studies for 2a-Cl suggest that complexes localize preferentially in the lysosomes and to a lesser extent in the cytoplasm, but ultimately causing damage to the mitochondria. Finally, the potential photodynamic behaviour of scarcely toxic complexes 2b-Cl, 2b-PF6, 2c-Cl and 3a-PF6 was also studied.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article