Synthesis and biological evaluation of novel 5-substituted/unsubstituted triazolothiadiazines as tubulin depolymerizing and vascular disrupting agents with promising antitumor activity.

Huo, Xian-Sen; Tang-Yang, Ji; Zeng, Wen-Bin; Jian, Xie-Er; Ma, Xuan-Xuan; Yue-Yang, Peng; Wen-Wei, You; Zhao, Pei-Liang

Huo, Xian-Sen; Tang-Yang, Ji; Zeng, Wen-Bin; Jian, Xie-Er; Ma, Xuan-Xuan; Yue-Yang, Peng; Wen-Wei, You; Zhao, Pei-Liang.

Afiliação

Huo XS; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, P.R.China.
Tang-Yang J; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, P.R.China.
Zeng WB; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, P.R.China.
Jian XE; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, P.R.China.
Ma XX; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, P.R.China.
Yue-Yang P; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, P.R.China.
Wen-Wei Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, P.R.China.
Zhao PL; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, P.R.China.

Drug Dev Res ; 84(5): 975-987, 2023 08.

Article em En | MEDLINE | ID: mdl-37089026

Assuntos

Antineoplásicos; Neoplasias Ovarianas; Tiadiazinas; Feminino; Humanos; Relação Estrutura-Atividade; Estrutura Molecular; Tubulina (Proteína)/metabolismo; Linhagem Celular Tumoral; Células HeLa; Tiadiazinas/farmacologia; Tiadiazinas/química; Células HEK293; Ensaios de Seleção de Medicamentos Antitumorais; Desenho de Fármacos; Moduladores de Tubulina/farmacologia; Moduladores de Tubulina/química; Proliferação de Células; Antineoplásicos/química; Apoptose

Palavras-chave

5-substituted/unsubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines; antiproliferative activity; tubulin polymerization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article