Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications.

Lu, Yang; Cao, Qiang; Yu, Yue; Sun, Yazhou; Jiang, Xuan; Li, Xin

Lu, Yang; Cao, Qiang; Yu, Yue; Sun, Yazhou; Jiang, Xuan; Li, Xin.

Afiliação

Lu Y; School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
Cao Q; School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
Yu Y; School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
Sun Y; The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
Jiang X; School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China. jiangx79@mail.sysu.edu.cn.
Li X; School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China. lixin253@mail.sysu.edu.cn.

BMC Genomics ; 24(1): 235, 2023 May 04.

Article em En | MEDLINE | ID: mdl-37138231

Assuntos

Metilação de DNA; Histonas; Humanos; Histonas/metabolismo; Código das Histonas; Carcinogênese/genética; Histona Desmetilases/genética; Histona Desmetilases/metabolismo; DNA/metabolismo; Ilhas de CpG; Fatores de Transcrição/metabolismo

Palavras-chave

Bivalent promoters; Cancer; DNA methylation; H3K4me1; LSD1; Promoter CGIs

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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