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Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months.
Allais, Christophe; Connor, Christina G; Do, Nga M; Kulkarni, Samir; Lee, Johnny W; Lee, Taegyo; McInturff, Emma; Piper, Jared; Place, Dave W; Ragan, John A; Weekly, R Matt.
Afiliação
  • Allais C; Pfizer Worldwide Research & Development, Chemical Research & Development, Groton, Connecticut 06355, United States.
  • Connor CG; Pfizer Worldwide Research & Development, Chemical Research & Development, Groton, Connecticut 06355, United States.
  • Do NM; Pfizer Worldwide Research & Development, Chemical Research & Development, Groton, Connecticut 06355, United States.
  • Kulkarni S; Pfizer Worldwide Research & Development, Chemical Research & Development, Groton, Connecticut 06355, United States.
  • Lee JW; Pfizer Worldwide Research & Development, Chemical Research & Development, Groton, Connecticut 06355, United States.
  • Lee T; Pfizer Worldwide Research & Development, Chemical Research & Development, Groton, Connecticut 06355, United States.
  • McInturff E; Pfizer Worldwide Research & Development, Chemical Research & Development, Groton, Connecticut 06355, United States.
  • Piper J; Pfizer Worldwide Research & Development, Chemical Research & Development, Groton, Connecticut 06355, United States.
  • Place DW; Pfizer Worldwide Research & Development, Chemical Research & Development, Groton, Connecticut 06355, United States.
  • Ragan JA; Pfizer Worldwide Research & Development, Chemical Research & Development, Groton, Connecticut 06355, United States.
  • Weekly RM; Pfizer Worldwide Research & Development, Chemical Research & Development, Groton, Connecticut 06355, United States.
ACS Cent Sci ; 9(5): 849-857, 2023 May 24.
Article em En | MEDLINE | ID: mdl-37252346
ABSTRACT
The advancement of nirmatrelvir, the active ingredient in Paxlovid, from discovery to emergency use authorization was achieved in just 17 months, requiring an unprecedented rate of chemical process development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article