A Complete Extension of Classical Hepatic Clearance Models Using Fractional Distribution Parameter f<sub>d</sub> in Physiologically Based Pharmacokinetics.

Jeong, Yoo-Seong; Jusko, William J

A Complete Extension of Classical Hepatic Clearance Models Using Fractional Distribution Parameter f_d in Physiologically Based Pharmacokinetics.

Jeong, Yoo-Seong; Jusko, William J.

Afiliação

Jeong YS; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Jusko WJ; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA. Electronic address: wjjusko@buffalo.edu.

J Pharm Sci ; 113(1): 95-117, 2024 01.

Article em En | MEDLINE | ID: mdl-37279835

Assuntos

Fígado; Modelos Biológicos; Ratos; Animais; Taxa de Depuração Metabólica; Fígado/metabolismo; Cinética; Farmacocinética

Palavras-chave

Classical models; Extended models; Fractional distribution parameter; Physiologically based pharmacokinetics (PBPK); Plasma and organ clearances

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article