Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines.

Courbon, Gautier M; Palme, Paul R; Mann, Lea; Richter, Adrian; Imming, Peter; Rubinstein, John L

Courbon, Gautier M; Palme, Paul R; Mann, Lea; Richter, Adrian; Imming, Peter; Rubinstein, John L.

Afiliação

Courbon GM; Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Palme PR; Department of Medical Biophysics, The University of Toronto, Toronto, ON, Canada.
Mann L; Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Saale, Germany.
Richter A; Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Saale, Germany.
Imming P; Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Saale, Germany.
Rubinstein JL; Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Saale, Germany.

EMBO J ; 42(15): e113687, 2023 08 01.

Article em En | MEDLINE | ID: mdl-37377118

Assuntos

Diarilquinolinas; Mycobacterium tuberculosis; Diarilquinolinas/farmacologia; Antituberculosos/farmacologia; Antituberculosos/química; Antituberculosos/metabolismo; Trifosfato de Adenosina/metabolismo; Mycobacterium tuberculosis/genética

Palavras-chave

ATP synthase; diarylquinoline; inhibitor; mycobacterial; squaramide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article