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Highly active nanoparticle enhanced rapid adsorption-killing mechanism to combat multidrug-resistant bacteria.
Xue, Yunyun; Zhao, Zihao; Huang, Wenbo; Qiu, Zelin; Li, Xiao; Zhao, Yu; Wang, Chuyao; Cui, Ronglu; Shen, Shuyang; Tian, Hua; Fang, Lifeng; Zhou, Rong; Zhu, Baoku.
Afiliação
  • Xue Y; Department of Polymer Science and Engineering, ERC of Membrane and Water Treatment (MOE), Key Laboratory of Macromolecular Synthesis and Functionalization (MOE), Zhejiang University, Hangzhou, 310027, China. fanglf@zju.edu.cn.
  • Zhao Z; Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, 312000, China. zhubk@zju.edu.cn.
  • Huang W; Department of Polymer Science and Engineering, ERC of Membrane and Water Treatment (MOE), Key Laboratory of Macromolecular Synthesis and Functionalization (MOE), Zhejiang University, Hangzhou, 310027, China. fanglf@zju.edu.cn.
  • Qiu Z; Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, 312000, China. zhubk@zju.edu.cn.
  • Li X; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China. zhourong@vip.163.com.
  • Zhao Y; Department of Polymer Science and Engineering, ERC of Membrane and Water Treatment (MOE), Key Laboratory of Macromolecular Synthesis and Functionalization (MOE), Zhejiang University, Hangzhou, 310027, China. fanglf@zju.edu.cn.
  • Wang C; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China. zhourong@vip.163.com.
  • Cui R; Department of Polymer Science and Engineering, ERC of Membrane and Water Treatment (MOE), Key Laboratory of Macromolecular Synthesis and Functionalization (MOE), Zhejiang University, Hangzhou, 310027, China. fanglf@zju.edu.cn.
  • Shen S; Department of Polymer Science and Engineering, ERC of Membrane and Water Treatment (MOE), Key Laboratory of Macromolecular Synthesis and Functionalization (MOE), Zhejiang University, Hangzhou, 310027, China. fanglf@zju.edu.cn.
  • Tian H; Department of Polymer Science and Engineering, ERC of Membrane and Water Treatment (MOE), Key Laboratory of Macromolecular Synthesis and Functionalization (MOE), Zhejiang University, Hangzhou, 310027, China. fanglf@zju.edu.cn.
  • Fang L; Department of Polymer Science and Engineering, ERC of Membrane and Water Treatment (MOE), Key Laboratory of Macromolecular Synthesis and Functionalization (MOE), Zhejiang University, Hangzhou, 310027, China. fanglf@zju.edu.cn.
  • Zhou R; Department of Polymer Science and Engineering, ERC of Membrane and Water Treatment (MOE), Key Laboratory of Macromolecular Synthesis and Functionalization (MOE), Zhejiang University, Hangzhou, 310027, China. fanglf@zju.edu.cn.
  • Zhu B; Department of Polymer Science and Engineering, ERC of Membrane and Water Treatment (MOE), Key Laboratory of Macromolecular Synthesis and Functionalization (MOE), Zhejiang University, Hangzhou, 310027, China. fanglf@zju.edu.cn.
J Mater Chem B ; 11(32): 7750-7765, 2023 09 06.
Article em En | MEDLINE | ID: mdl-37475586
Contact-killing surfaces with the ability to rapidly adsorb and kill microorganisms are desperately needed since the rapid outbreak of multidrug-resistant (MDR) bacteria poses a serious threat to human health. Therefore, a series of amphiphilic nanoengineered polyquaterniums (ANPQs) were synthesized, and immobilizing ANPQs onto equipment surfaces provided a simple method for preventing microbial infections. The strong charge-positive property of ANPQ offered the possibility of rapid adsorption and efficient killing, such that all bacteria are adsorbed after 10 seconds of contact with ANPQ-treated fabrics, and more than 99.99% of pathogens are killed within 30 seconds. Surprisingly, the adsorption-killing mechanism made it difficult for bacteria to develop resistance to ANPQ coating, even after long-term repeated treatment. Importantly, in a Methicillin-resistant Staphylococcus aureus infection model, ANPQ-treated fabrics exhibited a potent anti-infectious performance while remaining nontoxic. It is envisaged that the strategy of using ANPQ coating undoubtedly provides a promising candidate for fighting MDR strains.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article