Pimobendan prevents cardiac dysfunction, mitigates cardiac mitochondrial dysfunction, and preserves myocyte ultrastructure in a rat model of mitral regurgitation.

Boonpala, Pakit; Saengklub, Nakkawee; Srikam, Sirinapa; Ji-Au, Wilawan; Panyasing, Yaowalak; Kumphune, Sarawut; Kijtawornrat, Anusak

Boonpala, Pakit; Saengklub, Nakkawee; Srikam, Sirinapa; Ji-Au, Wilawan; Panyasing, Yaowalak; Kumphune, Sarawut; Kijtawornrat, Anusak.

Afiliação

Boonpala P; Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Saengklub N; Chulalongkorn University Laboratory Animal Center, Chulalongkorn University, Bangkok, Thailand.
Srikam S; Department of Physiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Ji-Au W; Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Panyasing Y; Department of Pathology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Kumphune S; Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Kijtawornrat A; Biomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai, Thailand.

BMC Vet Res ; 19(1): 130, 2023 Aug 23.

Article em En | MEDLINE | ID: mdl-37612694

Assuntos

Doenças do Cão; Insuficiência da Valva Mitral; Ratos; Animais; Cães; Insuficiência da Valva Mitral/tratamento farmacológico; Insuficiência da Valva Mitral/veterinária; Peróxido de Hidrogênio; Espécies Reativas de Oxigênio; Ratos Sprague-Dawley; Mitocôndrias; Células Musculares

Palavras-chave

Mitochondrial quality; Mitral regurgitation; Pimobendan; Rat; Reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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