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Autologous Bone Marrow Stem Cells in Patients With Critical Limb Ischaemia not Eligible for Revascularization: A Single Centre Experience.
Modugno, Pietro; Cilla, Savino; Centritto, Enrico Maria; Picone, Veronica; Maiorano, Maurizio; Amatuzio, Mariangela; Petrilli, Maria Pia; Fraticelli, Vincenzo; De Filippo, Carlo Maria; Caradonna, Eugenio; Codispoti, Franco Alberto; Massetti, Massimo; Tshomba, Yamume.
Afiliação
  • Modugno P; Vascular Surgery Unit, Gemelli Molise Hospital, Campobasso, Italy.
  • Cilla S; Medical Physics Unit, Gemelli Molise Hospital, Campobasso, Italy.
  • Centritto EM; Vascular Surgery Unit, Gemelli Molise Hospital, Campobasso, Italy.
  • Picone V; Vascular Surgery Unit, Gemelli Molise Hospital, Campobasso, Italy.
  • Maiorano M; Vascular Surgery Unit, Gemelli Molise Hospital, Campobasso, Italy.
  • Amatuzio M; Emergency Unit, Cardarelli Regional Hospital, ASREM, Campobasso, Italy.
  • Petrilli MP; Onco-haematology Unit, Gemelli Molise Hospital, Campobasso, Italy.
  • Fraticelli V; Onco-haematology Unit, Gemelli Molise Hospital, Campobasso, Italy.
  • De Filippo CM; Cardiac Surgery Unit, Gemelli Molise Hospital, Campobasso, Italy.
  • Caradonna E; Società italiana di medicina e chirurgia rigenerativa, Caserta, Italy.
  • Codispoti FA; Vascular Surgery Unit, Policlinico Universitario Campus Bio-Medico, Rome, Italy.
  • Massetti M; Cardiac Surgery Unit, Universita' Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Tshomba Y; Vascular Surgery Unit, Universita' Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Angiology ; : 33197231190512, 2023 Sep 20.
Article em En | MEDLINE | ID: mdl-37728082
ABSTRACT
We evaluated the use of autologus bone marrow stem cells transplantation in patients with critical limb ischaemia (CLI) not eligible for revascularization. Eighty consecutive patients candidate to amputation were enrolled in a single-centre retrospective study. The primary endpoint was defined as the amputation-free rate from stem cells transplantation. Secondary endpoints were the evaluation of transcutaneous oximetry and its predictive potential for probability of amputation and the evaluation of rest pain. Ankle brachial index, transcutaneous oxygen (TcpO2) and radiological imaging were performed at the enrolment and during the follow-up times. All patients were treated with auto transplant of bone marrow stem cells. Two patients died due to acute renal and acute respiratory failures. 19 patients were amputated from the thigh or leg. In total, 59 of 80 patients intended to thigh amputation saved the limb, preserving the plantar support. TcpO2 was found a predictive metric with an AUC equal to .763, and a threshold for a risk of amputation of 10% and 5% at the values ≤22.7 and ≤26.9 mmHg, respectively. Auto transplant of bone marrow stem cells seems to be a safe and an efficient option for CLI not eligible to revascularizzation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article