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L. pneumophila resists its self-harming metabolite HGA via secreted factors and collective peroxide scavenging.
Holland, Mische; Farinella, Danielle N; Cruz-Lorenzo, Emily; Laubscher, Madelyn I; Doakes, Darian A; Ramos, Maria A; Kubota, Nanami; Levin, Tera C.
Afiliação
  • Holland M; Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania, USA.
  • Farinella DN; Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania, USA.
  • Cruz-Lorenzo E; Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania, USA.
  • Laubscher MI; Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania, USA.
  • Doakes DA; Department of Plant and Microbial Biology, University of California Berkeley , Berkeley, California, USA.
  • Ramos MA; Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania, USA.
  • Kubota N; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA.
  • Levin TC; Department of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania, USA.
mBio ; 14(5): e0120723, 2023 Oct 31.
Article em En | MEDLINE | ID: mdl-37728338
IMPORTANCE: Before environmental opportunistic pathogens can infect humans, they must first successfully grow and compete with other microbes in nature, often via secreted antimicrobials. We previously discovered that the bacterium Legionella pneumophila, the causative agent of Legionnaires' disease, can compete with other microbes via a secreted molecule called HGA. Curiously, L. pneumophila strains that produce HGA is not wholly immune to its toxicity, making it a mystery how these bacteria can withstand the "friendly fire" of potentially self-targeting antimicrobials during inter-bacterial battles. Here, we identify several strategies that allow the high-density bacterial populations that secrete HGA to tolerate its effects. Our study clarifies how HGA works. It also points to some explanations of why it is difficult to disinfect L. pneumophila from the built environment and prevent disease outbreaks.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article