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Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients.
Klobucar, Iva; Vidovic, Luka; Arih, Ilona; Lechleitner, Margarete; Pregartner, Gudrun; Berghold, Andrea; Habisch, Hansjörg; Madl, Tobias; Frank, Sasa; Degoricija, Vesna.
Afiliação
  • Klobucar I; Department of Cardiology, Sisters of Charity University Hospital Centre, 10000 Zagreb, Croatia.
  • Vidovic L; Department of Medicine, Sisters of Charity University Hospital Centre, 10000 Zagreb, Croatia.
  • Arih I; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
  • Lechleitner M; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
  • Pregartner G; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria.
  • Berghold A; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria.
  • Habisch H; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
  • Madl T; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
  • Frank S; BioTechMed-Graz, 8010 Graz, Austria.
  • Degoricija V; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
Biomolecules ; 13(9)2023 Aug 29.
Article em En | MEDLINE | ID: mdl-37759723
Considering the relationship between disease severity and the extent of metabolic derangement in heart failure, we hypothesized that the serum levels of metabolites may have prognostic value for 1-year mortality in acute heart failure (AHF). The AHF study was a prospective, observational study enrolling consecutive patients hospitalized due to AHF. Metabolites were measured in serum collected at admission using NMR spectroscopy. Out of 315 AHF patients, 118 (37.5%) died within 1 year after hospitalization for AHF. The serum levels of 8 out of 49 identified metabolites were significantly different between patients who were alive and those who died within 1 year after hospitalization for AHF. Of these, only valine was significantly associated with 1-year mortality (hazard ratio 0.73 per 1 standard deviation increase, 95% confidence interval: 0.59-0.90, p = 0.003) in the multivariable Cox regression analyses. Kaplan-Maier analysis showed significantly higher survival rates in AHF patients with valine levels above the median (>279.2 µmol/L) compared to those with valine levels ≤ 279.2 µmol/L. In a receiver operating characteristics curve analysis, valine was able to discriminate between the two groups with an area under the curve of 0.65 (95% CI 0.59-0.72). We conclude that valine serum levels might be of prognostic value in AHF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article