Structure-based improvement of the binding affinity and recognition specificity of peptide competitors to target pediatric IL-5R/IL-5 interaction by gluing halogen bonds at their complex interface.

Chu, Peipei; Sheng, Yeping; Shen, Chentao; Xia, Yalin; Kong, Lingjun; Sun, Jiefan

Chu, Peipei; Sheng, Yeping; Shen, Chentao; Xia, Yalin; Kong, Lingjun; Sun, Jiefan.

Afiliação

Chu P; Department of Pediatric Medicine, Children's Hospital of Wujiang District, Soochow University, Suzhou, China.
Sheng Y; Department of Pediatric Medicine, Children's Hospital of Wujiang District, Soochow University, Suzhou, China.
Shen C; Department of Pediatric Medicine, Children's Hospital of Wujiang District, Soochow University, Suzhou, China.
Xia Y; Department of Pediatric Medicine, Children's Hospital of Wujiang District, Soochow University, Suzhou, China.
Kong L; Department of Pediatric Medicine, Children's Hospital of Soochow University, Suzhou, China.
Sun J; Department of Pediatric Medicine, Children's Hospital of Wujiang District, Soochow University, Suzhou, China.

J Mol Recognit ; 37(2): e3070, 2024 Mar.

Article em En | MEDLINE | ID: mdl-37990248

Assuntos

Halogênios; Interleucina-5; Humanos; Criança; Halogênios/química; Peptídeos/química; Proteínas

Palavras-chave

halogen bond; interleukin; molecular modeling; noncovalent interaction; pediatric disease; peptide

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Child / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Child / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article