Hydrazone-sulfonate hybrids as potential cholinesterase inhibitors: design, synthesis and molecular modeling simulation.

Omar, Mohamed A; El-Shiekh, Riham A; Dawood, Dina H; Temirak, Ahmed; Srour, Aladdin M

Omar, Mohamed A; El-Shiekh, Riham A; Dawood, Dina H; Temirak, Ahmed; Srour, Aladdin M.

Afiliação

Omar MA; Chemistry of Natural & Microbial Products Department, Pharmaceutical & Drug Industries Research Institute, National Research Centre, Dokki, Giza, 12622, Egypt.
El-Shiekh RA; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr el Aini St., Cairo, 11562, Egypt.
Dawood DH; Chemistry of Natural & Microbial Products Department, Pharmaceutical & Drug Industries Research Institute, National Research Centre, Dokki, Giza, 12622, Egypt.
Temirak A; Chemistry of Natural & Microbial Products Department, Pharmaceutical & Drug Industries Research Institute, National Research Centre, Dokki, Giza, 12622, Egypt.
Srour AM; Department of Therapeutic Chemistry, Pharmaceutical & Drug Industries Research Institute, National Research Centre, Dokki, Giza, 12622, Egypt.

Future Med Chem ; 15(24): 2269-2287, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37994559

Assuntos

Doença de Alzheimer; Inibidores da Colinesterase; Humanos; Inibidores da Colinesterase/química; Butirilcolinesterase/metabolismo; Acetilcolinesterase/metabolismo; Simulação de Acoplamento Molecular; Hidrazonas/farmacologia; Relação Estrutura-Atividade

Palavras-chave

Alzheimer's; cholinesterase; hydrazonesulfonate; molecular docking; toxicological bioassays

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article