Roles of vitamin Kdependent protein in biomineralization (Review).
Int J Mol Med
; 53(1)2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37997858
ABSTRACT
Vitamin K (VK), a fatsoluble vitamin, is well known as an anticoagulant in the clinic. It is essential for the posttranslational activation of VKdependent proteins (VKDPs) because hydroquinone VK is a cofactor of glutamine carboxylase. At present, 17 VKDPs are known, which are mainly involved in coagulation and calcification. When Glu residues are carboxylated to Gla residues, these proteins gain a higher calciumbinding ability, which explains why VK has an important role in blood coagulation and biomineralization. However, the current view on the role of VK and several VKDPs in biomineralization remains inconsistent. For instance, conflicting results have been reported regarding the effect of osteocalcin gene knockout on the bone of mice; matrix Gla protein (MGP) promotes osteoblasts mineralization but inhibits vascular smooth muscle cell mineralization. The present review aimed to summarize the existing evidence that several VKDPs, including osteocalcin, MGP, Glarich protein and growth arrest specific 6 are closely related to calcification, including bone health, vascular calcification and lithiasis. The current review discussed these controversies and provided suggestions for future studies on VKDPs, i.e. taking into account dietary habits, geographical environments and genetic backgrounds.
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01-internacional
Base de dados:
MEDLINE
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Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article