DOT1L decelerates the development of osteoporosis by inhibiting SRSF1 transcriptional activity via microRNA-181-mediated KAT2B inhibition.

Wang, Changsheng; Chen, Rongsheng; Zhu, Xitian; Zhang, Xiaobo; Lian, Nancheng

Wang, Changsheng; Chen, Rongsheng; Zhu, Xitian; Zhang, Xiaobo; Lian, Nancheng.

Afiliação

Wang C; Department of Spinal Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, PR China. Electronic address: wangchangsheng085@163.com.
Chen R; Department of Spinal Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, PR China.
Zhu X; Department of Spinal Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, PR China.
Zhang X; Department of Spinal Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, PR China.
Lian N; Department of Spinal Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, PR China.

Genomics ; 116(1): 110759, 2024 Jan.

Article em En | MEDLINE | ID: mdl-38072145

Assuntos

MicroRNAs; Osteoporose; Humanos; Osteogênese/genética; MicroRNAs/metabolismo; Osteoporose/genética; Diferenciação Celular/genética; Células Cultivadas; Histona-Lisina N-Metiltransferase; Fatores de Processamento de Serina-Arginina/genética; Fatores de Transcrição de p300-CBP/metabolismo

Palavras-chave

Bone marrow mesenchymal stem cells; DOT1L; Lysine acetyltransferase 2B; MicroRNA-181; Osteoclasts; Osteogenic differentiation; Osteoporosis; Serine and arginine rich splicing factor 1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article