Bioactive constituents from Trichilia dregeana Sond. (Meliaceae).
Nat Prod Res
; : 1-11, 2023 Dec 24.
Article
em En
| MEDLINE
| ID: mdl-38143307
ABSTRACT
The chemical investigation of the methanolic leaf extract of Trichilia dregeana Sond. led to the isolation of a hitherto unreported cycloartane-type triterpene, dregeanol (1), together with nine known compounds, (3ß,23E)-9,19-cyclolanosta-23,25-dien-3-ol (2), 9,19-cyclolanost-24-en-23-one (3), 6ß-hydroxystigmasta-4,22-dien-3-one (4), lyoniresinol (5), maslinic acid (6), asperphernamate (7), mixture of stigmasterol (8) and ß-sitosterol (9) and ß-sitosterol-3-O-ß-D-glucopyranoside (10). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. Compounds 2 and 6 showed significant antibacterial effect against Escherichia coli and Salmonella enteritidis, res-pectively, with MIC value of 31.25 µg/mL, whilst they displayed moderate antifungal effect with MIC value of 62.5 µg/mL against Candida albicans. All the isolates except compound 3 were found to possess a weak antioxidant potential in the DPPH, ABTS and FRAP assays.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article