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Home Oxygen After Hospitalization for COVID-19: Results From the Multi-Center OXFORD Study.
Freedman, Michael B; Kim, Yoo Jin; Kaur, Ramandeep; Jain, Bijal V; Adegunsoye, Ayodeji O; Chung, Yu-Che; DeLisa, Julie A; Gardner, Jessica M; Gordon, Howard S; Greenberg, Jared A; Kaul, Malvika; Khouzam, Nader; Labedz, Stephanie L; Mokhlesi, Babak; Rintz, Jacob; Rubinstein, Israel; Taylor, Analisa; Vines, David L; Ziauddin, Lubna; Gerald, Lynn B; Krishnan, Jerry A.
Afiliação
  • Freedman MB; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Kim YJ; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Kaur R; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Jain BV; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Adegunsoye AO; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Chung YC; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • DeLisa JA; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Gardner JM; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Gordon HS; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Greenberg JA; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Kaul M; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Khouzam N; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Labedz SL; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Mokhlesi B; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Rintz J; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Rubinstein I; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Taylor A; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Vines DL; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Ziauddin L; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Gerald LB; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
  • Krishnan JA; Drs Freedman and Kaul are affiliated with Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois; and Medical Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Drs Kim, Labedz, and Taylor and Ms Ziaud
Respir Care ; 69(3): 281-289, 2024 02 28.
Article em En | MEDLINE | ID: mdl-38176902
ABSTRACT

BACKGROUND:

In the first months of the pandemic, prior to the introduction of proven-effective treatments, 15-37% of patients hospitalized with COVID-19 were discharged on home oxygen. After proven-effective treatments for acute COVID-19 were established by evidence-based guidelines, little remains known about home oxygen requirements following hospitalization for COVID-19.

METHODS:

This was a retrospective, multi-center cohort study of subjects hospitalized for COVID-19 between October 2020-September 2021 at 3 academic health centers. Information was abstracted from electronic health records at the index hospitalization and for 60 d after discharge. The World Health Organization COVID-19 Clinical Progression Scale score was used to identify patients with severe COVID-19.

RESULTS:

Of 517 subjects (mean age 58 y, 47% female, 42% Black, 36% Hispanic, 22% with severe COVID-19), 81% were treated with systemic corticosteroids, 61% with remdesivir, and 2.5% with tocilizumab. About one quarter of subjects were discharged on home oxygen (26% [95% CI 22-29]). Older age (adjusted odds ratio [aOR] 1.02 per 5 y [95% CI 1.02-1.02]), higher body mass index (aOR 1.02 per kg/m2 [1.00-1.04]), diabetes (yes vs no, aOR 1.73 [1.46-2.02]), severe COVID-19 (vs moderate, aOR 3.19 [2.19-4.64]), and treatment with systemic corticosteroids (yes vs no, aOR 30.63 [4.51-208.17]) were associated with an increased odds of discharge on home oxygen. Comorbid hypertension (yes vs no, aOR 0.71 [0.66-0.77) was associated with a decreased odds of home oxygen. Within 60 d of hospital discharge, 50% had documentation of pulse oximetry; in this group, home oxygen was discontinued in 46%.

CONCLUSIONS:

About one in 4 subjects were prescribed home oxygen after hospitalization for COVID-19, even after guidelines established proven-effective treatments for acute illness. Evidence-based strategies to reduce the requirement for home oxygen in patients hospitalized for COVID-19 are needed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article