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Geriatric Assessment of Older Patients Receiving Trabectedin in First-Line Treatment for Advanced Soft Tissue Sarcomas: The E-TRAB Study from The German Interdisciplinary Sarcoma Group (GISG-13).
Kasper, Bernd; Pink, Daniel; Rothermundt, Christian; Richter, Stephan; Augustin, Marinela; Kollar, Attila; Kunitz, Annegret; Eisterer, Wolfgang; Gaidzik, Verena; Brodowicz, Thomas; Egerer, Gerlinde; Reichardt, Peter; Hohenberger, Peter; Schuler, Markus K.
Afiliação
  • Kasper B; Sarcoma Unit, Mannheim Cancer Center (MCC), Mannheim University Medical Center, University of Heidelberg, 68167 Mannheim, Germany.
  • Pink D; Department of Oncology and Palliative Care, HELIOS Klinikum Bad Saarow, 15526 Bad Saarow, Germany.
  • Rothermundt C; Department of Internal Medicine C, University Medicine Greifswald, 17475 Greifswald, Germany.
  • Richter S; Department of Medical Oncology and Hematology, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland.
  • Augustin M; Medical Department I, University Hospital Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, Germany.
  • Kollar A; Department of Hematology and Oncology, Paracelsus Medical University, 90419 Nuremberg, Germany.
  • Kunitz A; Department of Medical Oncology, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
  • Eisterer W; Department of Hematology, Oncology and Palliative Medicine, Vivantes Klinikum Spandau, 13585 Berlin, Germany.
  • Gaidzik V; Clinical Division of Oncology, Department of Internal Medicine, Medical University Graz, 8036 Graz, Austria.
  • Brodowicz T; Clinic for Internal Medicine III, University Hospital Ulm, 89081 Ulm, Germany.
  • Egerer G; Vienna General Hospital (AKH), Medizinische Universität Wien, 1090 Vienna, Austria.
  • Reichardt P; Department of Internal Medicine V, Heidelberg University Hospital, 69120 Heidelberg, Germany.
  • Hohenberger P; Department of Oncology, Helios Klinikum Berlin-Buch, 13125 Berlin, Germany.
  • Schuler MK; Division of Surgical Oncology and Thoracic Surgery, University Medical Center Mannheim, Mannheim Medical Faculty, University of Heidelberg, 68167 Mannheim, Germany.
Cancers (Basel) ; 16(3)2024 Jan 28.
Article em En | MEDLINE | ID: mdl-38339308
ABSTRACT
E-TRAB was a non-interventional, prospective trial investigating the feasibility and predictive value of geriatric assessments (GA) in older STS patients treated with trabectedin as first-line therapy. Primary endpoints were overall survival (OS), quality of life and individual clinical benefit assessed by the patient-reported outcome measures QLQ-C30 and PRO-CTCAE. Further, several GA tools were applied and correlated with clinical outcomes and treatment-related toxicities. The final analyses included 69 patients from 12 German-speaking sites. The median age of patients was 78 years (range 55 to 88). Baseline data on PROs and GA identified a diverse population of older patients with respect to their global health status, although a large proportion of them suffered from limitations, required geriatric help and had a high risk of morbidity. The Cancer and Age Research Group (CARG) score classified 38%, 29% and 23% of the patients with low, intermediate and high risks for therapy-related side effects, respectively. Median OS was 11.2 months [95%CI 5.6; 19.4]. The study confirmed that trabectedin as first-line treatment in older patients with STS has an acceptable and manageable safety profile. Potential prognostic factors for clinical outcome and therapy-related toxicity were identified among the GA tools. Long Timed Up and Go (TUG) showed a significant correlation to OS and early death, whereas a high CARG score (>9) was associated with an increase in unplanned hospitalizations and the incidence of toxicities grade ≥ 3.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2024 Tipo de documento: Article