Striatal Serotonin 4 Receptor is Increased in Experimental Parkinsonism and Dyskinesia.
J Parkinsons Dis
; 14(2): 261-267, 2024.
Article
em En
| MEDLINE
| ID: mdl-38339940
ABSTRACT
Alterations of serotonin type 4 receptor levels are linked to mood disorders and cognitive deficits in several conditions. However, few studies have investigated 5-HT4R alterations in movement disorders. We wondered whether striatal 5-HT4R expression is altered in experimental parkinsonism. We used a brain bank tissue from a rat and a macaque model of Parkinson's disease (PD). We then investigated its in vivo PET imaging regulation in a cohort of macaques. Dopaminergic depletion increases striatal 5-HT4R in the two models, further augmented after dyskinesia-inducing L-Dopa. Pending confirmation in PD patients, the 5-HT4R might offer a therapeutic target for dampening PD's symptoms.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article