Familial hypercholesterolemia in children and the importance of early treatment.
Curr Opin Lipidol
; 35(3): 126-132, 2024 06 01.
Article
em En
| MEDLINE
| ID: mdl-38363694
ABSTRACT
PURPOSE OF REVIEW Familial hypercholesterolemia leads to elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth onwards due to a pathogenetic variation in genes in cholesterol metabolism. Early screening to identify and subsequently treat children with familial hypercholesterolemia is crucial to reduce the risk of premature atherosclerotic cardiovascular disease (ASCVD). This review focuses on recent insights in the field of pediatric familial hypercholesterolemia. RECENT FINDINGS:
Screening in childhood and early initiation of optimal lipid-lowering therapy (LLT) have shown promising outcomes in the prevention of ASCVD. In addition, cost-effectiveness research has demonstrated highly favorable results. With the availability of novel therapies, familial hypercholesterolemia has become a well treatable disease.SUMMARY:
Children with familial hypercholesterolemia benefit from early detection and optimal treatment of their elevated LDL-C levels.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article