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Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM.
Bassetti, Matteo; Giacobbe, Daniele R; Agvald-Ohman, Christina; Akova, Murat; Alastruey-Izquierdo, Ana; Arikan-Akdagli, Sevtap; Azoulay, Elie; Blot, Stijn; Cornely, Oliver A; Cuenca-Estrella, Manuel; de Lange, Dylan W; De Rosa, Francesco G; De Waele, Jan J; Dimopoulos, George; Garnacho-Montero, Jose; Hoenigl, Martin; Kanj, Souha S; Koehler, Philipp; Kullberg, Bart J; Lamoth, Frédéric; Lass-Flörl, Cornelia; Maertens, Johan; Martin-Loeches, Ignacio; Muñoz, Patricia; Poulakou, Garyphallia; Rello, Jordi; Sanguinetti, Maurizio; Taccone, Fabio S; Timsit, Jean-François; Torres, Antoni; Vazquez, Jose A; Wauters, Joost; Asperges, Erika; Cortegiani, Andrea; Grecchi, Cecilia; Karaiskos, Ilias; Le Bihan, Clément; Mercier, Toine; Mortensen, Klaus L; Peghin, Maddalena; Rebuffi, Chiara; Tejada, Sofia; Vena, Antonio; Zuccaro, Valentina; Scudeller, Luigia; Calandra, Thierry.
Afiliação
  • Bassetti M; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy. matteo.bassetti@hsanmartino.it.
  • Giacobbe DR; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, L.go R. Benzi 10, 16132, Genoa, Italy. matteo.bassetti@hsanmartino.it.
  • Agvald-Ohman C; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  • Akova M; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, L.go R. Benzi 10, 16132, Genoa, Italy.
  • Alastruey-Izquierdo A; Anaesthesiology and Intensive Care, Karolinska University Hospital Huddinge, Stockholm, Sweden.
  • Arikan-Akdagli S; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Azoulay E; Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
  • Blot S; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Infecciosas-CIBERINFEC, Madrid, Spain.
  • Cornely OA; Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Cuenca-Estrella M; Université de Paris, Paris, France.
  • de Lange DW; Service de Médecine Intensive Et Réanimation, Hôpital Saint-Louis, AP-HP, Paris, France.
  • De Rosa FG; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
  • De Waele JJ; UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
  • Dimopoulos G; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Garnacho-Montero J; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
  • Hoenigl M; Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.
  • Kanj SS; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
  • Koehler P; Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
  • Kullberg BJ; Department of Intensive Care Medicine, University Medical Center, University Utrecht, Utrecht, The Netherlands.
  • Lamoth F; Department of Medical Sciences, Infectious Diseases, University of Turin, Turin, Italy.
  • Lass-Flörl C; Department of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium.
  • Maertens J; Department of Critical Care, University Hospital Attikon, Attikon Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Martin-Loeches I; Intensive Care Unit, Virgen del Rocío University Hospital, Seville, Spain.
  • Muñoz P; Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
  • Poulakou G; BioTechMed, Graz, Austria.
  • Rello J; Translational Mycology Working Group, ECMM Excellence Center for Clinical Mycology, Medical University of Graz, Graz, Austria.
  • Sanguinetti M; Division of Infectious Diseases, and Center for Infectious Diseases Research, American University of Beirut Medical Center, Beirut, Lebanon.
  • Taccone FS; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Timsit JF; Medical Faculty and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
  • Torres A; Department of Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Vazquez JA; Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Wauters J; Service of Immunology and Allergy and Center of Human Immunology Lausanne, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Asperges E; Department of Laboratory Medicine and Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Cortegiani A; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
  • Grecchi C; Universitair Ziekenhuis Leuven, Louvain, Belgium.
  • Karaiskos I; Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James' Hospital, Dublin, Ireland.
  • Le Bihan C; Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Mercier T; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
  • Mortensen KL; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias-CIBERES (CB06/06/0058), Madrid, Spain.
  • Peghin M; Medicine Department, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain.
  • Rebuffi C; Third Department of Internal Medicine, School of Medicine, Sotiria General Hospital, National and Kapodistrian University, Athens, Greece.
  • Tejada S; Clinical Research/Epidemiology in Pneumonia and Sepsis (CRIPS), Vall d'Hebron Institut of Research (VHIR), Barcelona, Spain.
  • Vena A; Clinical Research in the ICU, CHU Nimes, Universite de Nimes-Montpellier, Nimes, France.
  • Zuccaro V; Medicine Department, Universitat Internacional de Catalunya (UIC), Sant Cugat, Spain.
  • Scudeller L; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
  • Calandra T; Dipartimento di Scienze di Laboratorio E Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Intensive Care Med ; 50(4): 502-515, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38512399
ABSTRACT

PURPOSE:

The aim of this document was to develop standardized research definitions of invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted to intensive care units (ICUs).

METHODS:

After a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method.

RESULTS:

Standardized research definitions were developed for proven invasive candidiasis, probable deep-seated candidiasis, proven invasive aspergillosis, probable invasive pulmonary aspergillosis, and probable tracheobronchial aspergillosis. The limited evidence on the performance of existing definitions and laboratory tests for the diagnosis of IFD other than candidiasis and aspergillosis precluded the development of dedicated definitions, at least pending further data. The standardized definitions provided in the present document are aimed to speed-up the design, and increase the feasibility, of future comparative research studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adult / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adult / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article