Evaluating the diagnostic and prognostic ability of ischemia modified albumin in COVID-19.
Heart Lung
; 66: 16-22, 2024.
Article
em En
| MEDLINE
| ID: mdl-38520986
ABSTRACT
BACKGROUND:
Patients with COVID-19 can rapidly deteriorate and develop acute hypoxic respiratory failure. Prominent features of the disease include severe inflammation, endotheliitis, and thrombosis.OBJECTIVES:
The aim of the study was to evaluate the diagnostic and prognostic effectiveness of ischemia modified albumin (ΙΜΑ) in a cohort of COVID-19 patients.METHODS:
This prospective observational study included adults with SARS-CoV-2 infection confirmed by reverse transcription polymerase chain reaction test, who were hospitalized specifically for COVID-19. The outcomes of interest were progression to severe acute respiratory failure during the index hospitalization defined as partial pressure of oxygen/fraction of inspired oxygen lower or equal to 150, admission to the intensive care unit (ICU) and in-hospital mortality. Admission IMA levels were determined using the commercially available "IMA Assay Kit" method (Abbexa LTD, Cambridge, UK). Adults without SARS-CoV-2 infection were used as controls.RESULTS:
135 COVID-19 patients and 64 controls were included. Admission IMA levels were significantly higher in COVID-19 patients compared to controls [[24.38 (11.94) ng/ml vs. 14.69 (3.52) ng/ml, p < 0.01]. Receiver operating characteristic analysis of admission IMA showed an area under the curve (AUC) of 94% (p < 0.0001) for COVID-19 diagnosis (cut-off value 17.5 ng/ml; sensitivity 90.37%; specificity 87.5%). Admission IMA was also associated with mortality (AUC 68%, p = 0.01). However, it was not associated with severe acute respiratory failure (AUC 47%, p = 0.53) or ICU admission (AUC 58%, p = 0.41).CONCLUSION:
Admission IMA was significantly increased in COVID-19 patients and was associated with in-hospital mortality.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article