PyrAtes: Modular Organic Salts with Large Stokes Shifts for Fluo-rescence Microscopy.
Angew Chem Int Ed Engl
; 63(19): e202318127, 2024 05 06.
Article
em En
| MEDLINE
| ID: mdl-38570814
ABSTRACT
The deployment of small-molecule fluorescent agents plays an ever-growing role in medicine and drug development. Herein, we complement the portfolio of powerful fluorophores, reporting the serendipitous discovery and development of a novel class with an imidazo[1,2-a]pyridinium triflate core, which we term PyrAtes. These fluorophores are synthesized in a single step from readily available materials (>60â
examples) and display Stokes shifts as large as 240â
nm, while also reaching NIR-I emissions at λmax as long as 720â
nm. Computational studies allow the development of a platform for the prediction of λmax and λEm. Furthermore, we demonstrate the compatibility of these novel fluorophores with live cell imaging in HEK293 cells, suggesting PyrAtes as potent intracellular markers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article