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Mapping Early Brain-Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity.
Pollatou, Angeliki; Holland, Cristin M; Stockton, Thirsten J; Peterson, Bradley S; Scheinost, Dustin; Monk, Catherine; Spann, Marisa N.
Afiliação
  • Pollatou A; Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032.
  • Holland CM; Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032.
  • Stockton TJ; Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032.
  • Peterson BS; Institute for the Developing Mind, Children's Hospital Los Angeles, Los Angeles, California 90027.
  • Scheinost D; Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, California 90033.
  • Monk C; Departments of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut 06520.
  • Spann MN; Child Study Center, Yale School of Medicine, New Haven, Connecticut 06520.
J Neurosci ; 44(22)2024 May 29.
Article em En | MEDLINE | ID: mdl-38604780
ABSTRACT
The autonomic nervous system (ANS) regulates the body's physiology, including cardiovascular function. As the ANS develops during the second to third trimester, fetal heart rate variability (HRV) increases while fetal heart rate (HR) decreases. In this way, fetal HR and HRV provide an index of fetal ANS development and future neurobehavioral regulation. Fetal HR and HRV have been associated with child language ability and psychomotor development behavior in toddlerhood. However, their associations with postbirth autonomic brain systems, such as the brainstem, hypothalamus, and dorsal anterior cingulate cortex (dACC), have yet to be investigated even though brain pathways involved in autonomic regulation are well established in older individuals. We assessed whether fetal HR and HRV were associated with the brainstem, hypothalamic, and dACC functional connectivity in newborns. Data were obtained from 60 pregnant individuals (ages 14-42) at 24-27 and 34-37 weeks of gestation using a fetal actocardiograph to generate fetal HR and HRV. During natural sleep, their infants (38 males and 22 females) underwent a fMRI scan between 40 and 46 weeks of postmenstrual age. Our findings relate fetal heart indices to brainstem, hypothalamic, and dACC connectivity and reveal connections with widespread brain regions that may support behavioral and emotional regulation. We demonstrated the basic physiologic association between fetal HR indices and lower- and higher-order brain regions involved in regulatory processes. This work provides the foundation for future behavioral or physiological regulation research in fetuses and infants.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adolescent / Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adolescent / Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article