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Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner.
Karagianni, Aikaterini; Karkempetzaki, Anastasia Iris; Brooks, Daniel; Matsuura, Shinobu; Dambal, Vrinda; Trackman, Philip C; Ravid, Katya.
Afiliação
  • Karagianni A; Department of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
  • Karkempetzaki AI; Department of Internal Medicine, University of Crete, School of Medicine, Heraklion, Greece.
  • Brooks D; Department of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
  • Matsuura S; Department of Internal Medicine, University of Crete, School of Medicine, Heraklion, Greece.
  • Dambal V; Center for Musculoskeletal Research, Endocrine Unit, Massachusetts General Hospital, Boston, MA.
  • Trackman PC; Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA.
  • Ravid K; Department of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Blood ; 143(25): 2666-2670, 2024 Jun 20.
Article em En | MEDLINE | ID: mdl-38635757
ABSTRACT
ABSTRACT Lysyl oxidase (LOX) is a facilitator of extracellular matrix cross-linking. Using newly developed megakaryocyte-specific LOX knockout mice, we show that LOX expressed in these scarce bone marrow cells affects bone volume and collagen architecture in a sex-dependent manner.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article