Effects of goal-directed analgesia using the analgesia nociception index in children undergoing surgery for moyamoya disease: A randomised controlled trial.
Eur J Anaesthesiol
; 41(9): 649-656, 2024 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-38832435
ABSTRACT
BACKGROUND:
The potential benefits of Analgesia Nociception Index guided intra-operative analgesia on intra-operative opioid consumption remains to be demonstrated in paediatric anaesthesia.OBJECTIVES:
This study aimed to explore the effects of Analgesia Nociception Index guided analgesia on sufentanil consumption during anaesthesia and postoperative pain scores in paediatric patients with moyamoya disease.DESIGN:
A prospective randomised controlled study.SETTING:
Seoul National University Children's Hospital, Seoul, Republic of Korea. PATIENTS A total of 40 children scheduled for encephaloduroarteriosynangiosis. MAIN OUTCOMEMEASURES:
The primary outcome was total intra-operative sufentanil consumption, and the secondary outcomes included postoperative pain scores and incidence of opioid-related adverse events.RESULTS:
The Analgesia Nociception Index group showed lower intra-operative sufentanil consumption (in µgâkg -1 âh -1 ) compared with the Standard group (0.30â±â0.12 and 0.39â±â0.17, respectively; mean difference, -0.09; 95% confidence interval, -0.19 to 0.00; P â=â0.049). Postoperatively, compared with the Standard group, the Analgesia Nociception Index group reported lower median pain scores at 18 and 24âh and maximum pain within 24âh (1 [0 to 2] vs. 3 [2 to 5]; P â=â0.004, 1 [0 to 2] vs. 3 [1 to 4]; P â=â0.041, and 4 [3 to 5] vs. 5 [4 to 7]; P â=â0.045, respectively), with fewer patients experiencing nausea (3 [15%] vs. 10 [50%], P â=â0.043).CONCLUSION:
The Analgesia Nociception Index guided analgesic protocol can reduce intra-operative sufentanil consumption and postoperative pain within 24âh with fewer nausea symptoms in paediatric patients with moyamoya disease who undergo encephaloduroarteriosynangiosis. TRIAL REGISTRATION NUMBER NCT05672212.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article