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Ribosomal DNA copy number is associated with body mass in humans and other mammals.
Law, Pui Pik; Mikheeva, Liudmila A; Rodriguez-Algarra, Francisco; Asenius, Fredrika; Gregori, Maria; Seaborne, Robert A E; Yildizoglu, Selin; Miller, James R C; Tummala, Hemanth; Mesnage, Robin; Antoniou, Michael N; Li, Weilong; Tan, Qihua; Hillman, Sara L; Rakyan, Vardhman K; Williams, David J; Holland, Michelle L.
Afiliação
  • Law PP; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, UK.
  • Mikheeva LA; The Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Rodriguez-Algarra F; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, UK.
  • Asenius F; The Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Gregori M; UCL EGA Institute for Women's Health, University College London, London, UK.
  • Seaborne RAE; UCL EGA Institute for Women's Health, University College London, London, UK.
  • Yildizoglu S; The Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Miller JRC; Centre for Human and Applied Physiological Studies, King's College London, London, UK.
  • Tummala H; The Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Mesnage R; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, UK.
  • Antoniou MN; The Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Li W; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, UK.
  • Tan Q; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, UK.
  • Hillman SL; Population Research Unit, University of Helsinki, Helsinki, Finland.
  • Rakyan VK; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Copenhagen, Denmark.
  • Williams DJ; UCL EGA Institute for Women's Health, University College London, London, UK.
  • Holland ML; The Blizard Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Nat Commun ; 15(1): 5006, 2024 Jun 12.
Article em En | MEDLINE | ID: mdl-38866738
ABSTRACT
Body mass results from a complex interplay between genetics and environment. Previous studies of the genetic contribution to body mass have excluded repetitive regions due to the technical limitations of platforms used for population scale studies. Here we apply genome-wide approaches, identifying an association between adult body mass and the copy number (CN) of 47S-ribosomal DNA (rDNA). rDNA codes for the 18 S, 5.8 S and 28 S ribosomal RNA (rRNA) components of the ribosome. In mammals, there are hundreds of copies of these genes. Inter-individual variation in the rDNA CN has not previously been associated with a mammalian phenotype. Here, we show that rDNA CN variation associates with post-pubertal growth rate in rats and body mass index in adult humans. rDNA CN is not associated with rRNA transcription rates in adult tissues, suggesting the mechanistic link occurs earlier in development. This aligns with the observation that the association emerges by early adulthood.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adult / Animals / Female / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adult / Animals / Female / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article