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Homoharringtonine inhibits the NOTCH/MYC pathway and exhibits antitumor effects in T-cell acute lymphoblastic leukemia.
Suo, Shanshan; Zhao, Dandan; Li, Fenglin; Zhang, Yi; Rodriguez-Rodriguez, Sonia; Nguyen, Le Xuan Truong; Ghoda, Lucy; Carlesso, Nadia; Marcucci, Guido; Zhang, Bin; Jin, Jie.
Afiliação
  • Suo S; Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
  • Zhao D; Hematology Malignancies Research Institute, Gehr Family Center for Leukemia Research, City of Hope Medical Center, Duarte, CA.
  • Li F; Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy, Zhejiang University, Hangzhou, People's Republic of China.
  • Zhang Y; Zhejiang University Cancer Center, Hangzhou, People's Republic of China.
  • Rodriguez-Rodriguez S; Hematology Malignancies Research Institute, Gehr Family Center for Leukemia Research, City of Hope Medical Center, Duarte, CA.
  • Nguyen LXT; Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy, Zhejiang University, Hangzhou, People's Republic of China.
  • Ghoda L; Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
  • Carlesso N; Hematology Malignancies Research Institute, Gehr Family Center for Leukemia Research, City of Hope Medical Center, Duarte, CA.
  • Marcucci G; Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy, Zhejiang University, Hangzhou, People's Republic of China.
  • Zhang B; Zhejiang University Cancer Center, Hangzhou, People's Republic of China.
  • Jin J; Hematology Malignancies Research Institute, Gehr Family Center for Leukemia Research, City of Hope Medical Center, Duarte, CA.
Blood ; 144(12): 1343-1347, 2024 Sep 19.
Article em En | MEDLINE | ID: mdl-38968151
ABSTRACT
ABSTRACT We report on the antileukemic activity of homoharringtonine (HHT) in T-cell acute lymphoblastic leukemia (T-ALL). We showed that HHT inhibited the NOTCH/MYC pathway and induced significantly longer survival in mouse and patient-derived T-ALL xenograft models, supporting HHT as a promising agent for T-ALL.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article