Your browser doesn't support javascript.
loading
Glucagon Clearance is Decreased in Chronic Kidney Disease, but Preserved in Liver Cirrhosis.
Grøndahl, Magnus F G; Lange, Andreas H; Suppli, Malte P; Bagger, Jonatan I; Thing, Mira; Gluud, Lise L; Kofod, Dea H; Hornum, Mads; Van Hall, Gerrit; Trammell, Samuel A J; Grevengoed, Trisha J; Hartmann, Bolette; Holst, Jens J; Vilsbøll, Tina; Christensen, Mikkel B; Lund, Asger B; Knop, Filip K.
Afiliação
  • Grøndahl MFG; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Lange AH; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Suppli MP; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Bagger JI; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Thing M; Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark.
  • Gluud LL; Gastro Unit, Medical Unit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
  • Kofod DH; Gastro Unit, Medical Unit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
  • Hornum M; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Van Hall G; Department of Nephrology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Trammell SAJ; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Grevengoed TJ; Department of Nephrology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Hartmann B; Clinical Metabolomics Core Facility, Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Holst JJ; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Vilsbøll T; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Christensen MB; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Lund AB; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Knop FK; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Diabetes ; 2024 Jul 25.
Article em En | MEDLINE | ID: mdl-39052774
ABSTRACT
It is not completely clear which organs are responsible for glucagon elimination in humans, and disturbances in the elimination of glucagon could contribute to the hyperglucagonemia observed in chronic liver disease and chronic kidney disease (CKD). Here, we evaluated kinetics and metabolic effects of exogenous glucagon in individuals with stage 4 CKD (n =16), individuals with Child-Pugh A-C cirrhosis (n = 16) and matched control individuals (n = 16), before, during and after a 60-minute glucagon infusion (4 ng/kg/min). Individuals with CKD exhibited a significantly lower mean metabolic clearance rate of glucagon (14.0 [95% CI 12.2;15.7] mL/kg/min) both compared to individuals with cirrhosis (19.7 [18.1;21.3] mL/kg/min, P < 0.001) and to control individuals (20.4 [18.1;22.7] mL/kg/min, P < 0.001). Glucagon half-life was significantly prolonged in the CKD group (7.5 [6.9;8.2] minutes) compared to individuals with cirrhosis (5.7 [5.2;6.3] minutes, P = 0.002) and control individuals (5.7 [5.2;6.3] minutes, P < 0.001). No difference in the effects of exogenous glucagon on plasma glucose, amino acids, or triglycerides was observed between groups. In conclusion, chronic kidney disease, but not liver cirrhosis leads to a significant reduction in glucagon clearance, supporting the kidneys as a primary site for human glucagon elimination.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article