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A Multicomponent Microneedle Patch for the Delivery of Meloxicam for Veterinary Applications.
Miranda-Muñoz, Katherine; Midkiff, Kirsten; Woessner, Alan; Afshar-Mohajer, Mahyar; Zou, Min; Pollock, Erik; Gonzalez-Nino, David; Prinz, Gary; Hutchinson, Lillian; Li, Ruohan; Kompalage, Kushan; Culbertson, Christopher T; Tucker, Ryan Jared; Coetzee, Hans; Tsai, Tsung; Powell, Jeremy; Almodovar, Jorge.
Afiliação
  • Miranda-Muñoz K; Department of Biomedical Engineering, College of Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
  • Midkiff K; Department of Animal Sciences, University of Arkansas, B110 Agriculture, Food and Life Sciences Building, Fayetteville, Arkansas 72701, United States.
  • Woessner A; Department of Biomedical Engineering, College of Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
  • Afshar-Mohajer M; Arkansas Integrative Metabolic Research Center, University of Arkansas, Fayetteville, Arkansas 72701, United States.
  • Zou M; Department of Mechanical Engineering, University of Arkansas, 204 Mechanical Engineering Building, Fayetteville, Arkansas 72701, United States.
  • Pollock E; Department of Mechanical Engineering, University of Arkansas, 204 Mechanical Engineering Building, Fayetteville, Arkansas 72701, United States.
  • Gonzalez-Nino D; Department of Biological Sciences, University of Arkansas, Fayetteville, Science Engineering Building, Fayetteville, Arkansas 72701, United States.
  • Prinz G; Department of Civil Engineering, University of Arkansas, 4190 Bell Engineering Center, Fayetteville, Arkansas 72701, United States.
  • Hutchinson L; Department of Civil Engineering, University of Arkansas, 4190 Bell Engineering Center, Fayetteville, Arkansas 72701, United States.
  • Li R; Ralph E. Martin Department of Chemical Engineering, University of Arkansas, 3202 Bell Engineering Center, Fayetteville, Arkansas 72701, United States.
  • Kompalage K; Ralph E. Martin Department of Chemical Engineering, University of Arkansas, 3202 Bell Engineering Center, Fayetteville, Arkansas 72701, United States.
  • Culbertson CT; Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, 213 CBC Building, 1212 Mid-Campus Dr North, Manhattan, Kansas 66506, United States.
  • Tucker RJ; Department of Chemistry, Kansas State University, 228 Coles Hall, 1710 Denison Ave, Manhattan, Kansas 66506, United States.
  • Coetzee H; Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, 213 CBC Building, 1212 Mid-Campus Dr North, Manhattan, Kansas 66506, United States.
  • Tsai T; Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, 213 CBC Building, 1212 Mid-Campus Dr North, Manhattan, Kansas 66506, United States.
  • Powell J; Department of Animal Sciences, University of Arkansas, B110 Agriculture, Food and Life Sciences Building, Fayetteville, Arkansas 72701, United States.
  • Almodovar J; Department of Animal Sciences, University of Arkansas, B110 Agriculture, Food and Life Sciences Building, Fayetteville, Arkansas 72701, United States.
ACS Nano ; 18(37): 25716-25739, 2024 Sep 17.
Article em En | MEDLINE | ID: mdl-39225687
ABSTRACT
This study evaluates the use of poly(vinyl alcohol), collagen, and chitosan blends for developing a microneedle patch for the delivery of meloxicam (MEL). Results confirm successful MEL encapsulation, structural integrity, and chemical stability even after ethylene oxide sterilization. Mechanical testing indicates the patch has the required properties for effective skin penetration and drug delivery, as demonstrated by load-displacement curves showing successful penetration of pig ear surfaces at 3N of normal load. In vitro imaging confirms the microneedle patch penetrates the pig's ear cadaver skin effectively and uniformly, with histological evaluation revealing the sustained presence and gradual degradation of microneedles within the skin. Additionally, in vitro drug diffusion experiments utilizing ballistic gel suggest that microneedles commence dissolution almost immediately upon insertion into the gel, steadily releasing the drug over 24 h. Furthermore, the microneedle patch demonstrates ideal drug release capabilities, achieving nearly 100% release of meloxicam content from a single patch within 18 h. Finally, in vivo studies using pigs demonstrate the successful dissolution and transdermal drug delivery efficacy of biodegradable microneedle patches delivering meloxicam in a porcine model, with over 70% of microneedles undergoing dissolution after 3 days. While low detectable meloxicam concentrations were observed in the bloodstream, high levels were detected in the ear tissue, confirming the release and diffusion of the drug from microneedles. This work highlights the potential of microneedle patches for controlled drug release in veterinary applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article