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Effectiveness of treatment with budesonide orodispersible tablets in 76 patients with eosinophilic oesophagitis - real-life experience from the population-based DanEoE cohort.
Frandsen, Line Tegtmeier; Melgaard, Dorte; Hansen, Stine Kjærsgaard; Mørk, Kasper; Krarup, Anne Lund.
Afiliação
  • Frandsen LT; Department of Gastroenterology, North Denmark Regional Hospital, Hjørring, Denmark.
  • Melgaard D; Department of Emergency Medicine and Trauma Center, Aalborg University Hospital, Aalborg, Denmark.
  • Hansen SK; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Mørk K; Department of Emergency Medicine and Trauma Center, Aalborg University Hospital, Aalborg, Denmark.
  • Krarup AL; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Scand J Gastroenterol ; 59(10): 1137-1143, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39267404
ABSTRACT

BACKGROUND:

Eosinophilic oesophagitis (EoE) is a chronic immune-mediated disease. In Denmark, the budesonide orodispersible tablet (BOT) is recommended as a second-line treatment for proton pump inhibitor-refractory EoE patients.

AIMS:

To evaluate the effectiveness of treatment with BOT in adult EoE patients in a population-based setting in Denmark.

METHODS:

This was a retrospective, registry-based, DanEoE cohort study of all 76 adult EoE patients treated with BOT and diagnosed between 2007 and 2021 in the North Denmark Region. After medical record revision, the EoE diagnosis was defined according to the AGREE consensus. Symptomatic response was based on the information found in the patients' medical reports and histologic remission was defined as <15 eosinophils per high-power field (eos/hpf).

RESULTS:

Histologic remission was achieved in 89% of the patients treated with BOT who underwent histologic evaluation. Clinicohistologic remission was achieved in 71% of the patients who underwent both symptomatic and histologic evaluation. Despite histologic remission, 18% of patients still experienced symptoms. Non-responders were found in 7% of the patients. Complications were rare, with dilation of strictures performed in 7% and food bolus obstruction (FBO) occurring in 3%. Discontinuation of the treatment due to unacceptable side effects was observed in 11% of the treated patients.

CONCLUSIONS:

Treatment with BOT effectively induced histologic remission in most of the EoE patients. Despite achieving histologic remission, approximately 1/5 of the patients were still symptomatic. Complications were rare. In non-responders and those with unacceptable side effects, alternative treatment options such as biologic agents might be needed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article