Concordant segregation of the expression of SV40 T antigen and human chromosome 7 in mouse-human hybrid subclones.
J Exp Med
; 139(5): 1350-3, 1974 May 01.
Article
em En
| MEDLINE
| ID: mdl-4363410
ABSTRACT
Subcloning of Simian virus 40 (SV40) T antigen-positive mouse-human hybrids, derived from the fusion of mouse cells deficient in thymidine kinase with SV40-transformed Lesch Nyhan fibroblasts, resulted in their segregation into T antigen-positive and negative subclones. Positive correlation between the presence of human chromosome 7 and the expression of SV40 T antigen was established in the subclones examined. These results negate the possibility of a transfer of the SV40 genome to a mouse chromosome.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1974
Tipo de documento:
Article