RET/PTC oncogene activation is an early event in thyroid carcinogenesis.
Oncogene
; 11(6): 1207-10, 1995 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-7566982
ABSTRACT
RET/PTC oncogene activation occurs in about 20% of human thyroid papillary carcinomas. However, it is not known yet whether it is an early or late event in the process of thyroid carcinogenesis. Here we demonstrate, by using a combined immunohistochemical and reverse transcriptase-polymerase chain reaction based approach, that RET/PTC activation is present in 11 out of 26 occult thyroid papillary carcinomas analysed. Therefore, we conclude that it represents an early event in the process of thyroid cell transformation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Humans
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article