Stereoselective disposition of ibuprofen enantiomers in infants.
Br J Clin Pharmacol
; 38(4): 373-5, 1994 Oct.
Article
em En
| MEDLINE
| ID: mdl-7833229
ABSTRACT
The pharmacokinetics of the enantiomers of ibuprofen were investigated after oral administration of a single 7.6 +/- 0.3 mg kg-1 dose of the racemate in 11 infants. Mean (+/- s.d.) half-lives were 1.6 +/- 0.5 h for S(+) and 1.5 +/- 0.5 h for R(-) and mean (+/- s.d.) AUC values were 31.5 +/- 14.3 mg l-1 h for S(+) and 36.6 +/- 13.8 mg l-1 h for R(-). Since plasma concentrations of the active S(+)-isomer were lower than those reported in adults, a higher dosage might be required in infants.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article