A permanently charged tamoxifen derivative displays anticancer activity and improved tissue selectivity in rodents.
Cancer Res
; 56(19): 4328-31, 1996 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-8813117
ABSTRACT
A quaternized form of tamoxifen (TAM), tamoxifen methiodide (TMI), was shown to demonstrate very low brain uptake compared to TAM and, unexpectedly, was considerably less estrogenic than TAM in the uterus. The agonist activity of TMI in the bone was similar to that of TAM. TMI manifested significant dose-dependent tumoricidal activity with a rapid onset of action against MCF-7 human breast cancer implants in nude mice and a mean reduction in tumor size of 60% over six weeks.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article