Determinants of disease in the simian immunodeficiency virus-infected rhesus macaque: characterizing animals with low antibody responses and rapid progression.
J Gen Virol
; 79 ( Pt 10): 2461-7, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-9780052
ABSTRACT
Clinical and laboratory markers of simian immunodeficiency virus (SIV) infection were studied during the first 3 months after intravenous inoculation of rhesus macaques. Virus-binding serum antibody titres were correlated strongly with disease progression (P < 0.005) and were predictive of disease outcome by 7 weeks after inoculation. Low virus-binding serum antibody responses to SIV occurred in animals that also showed acute depletion of circulating CD20+ B cells. Acute damage to the CD4+ T cell and CD20+ B cell populations rendered some animals incapable of mounting virus-specific antibody responses and these macaques became the rapidly progressing cases comprising approximately 20-30% of infected animal cohorts.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article