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Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.
Fox, J W; Lamperti, E D; Eksioglu, Y Z; Hong, S E; Feng, Y; Graham, D A; Scheffer, I E; Dobyns, W B; Hirsch, B A; Radtke, R A; Berkovic, S F; Huttenlocher, P R; Walsh, C A.
Afiliação
  • Fox JW; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA.
Neuron ; 21(6): 1315-25, 1998 Dec.
Article em En | MEDLINE | ID: mdl-9883725
ABSTRACT
Long-range, directed migration is particularly dramatic in the cerebral cortex, where postmitotic neurons generated deep in the brain migrate to form layers with distinct form and function. In the X-linked dominant human disorder periventricular heterotopia (PH), many neurons fail to migrate and persist as nodules lining the ventricular surface. Females with PH present with epilepsy and other signs, including patent ductus arteriosus and coagulopathy, while hemizygous males die embryonically. We have identified the PH gene as filamin 1 (FLN1), which encodes an actin-cross-linking phosphoprotein that transduces ligand-receptor binding into actin reorganization, and which is required for locomotion of many cell types. FLN1 shows previously unrecognized, high-level expression in the developing cortex, is required for neuronal migration to the cortex, and is essential for embryogenesis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 1998 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 1998 Tipo de documento: Article